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B21682	紫草素
源葉	分析標(biāo)準(zhǔn)品,HPLC≥98%

英文名：
Shikonin

別名：
5,8-二羥基-2-[(1R)-1-羥基-4-甲基戊-3-烯基]萘-1,4-二酮

CAS號(hào)：
517-89-5

分子式：
C₁₆H₁₆O₅

分子量：
288.299

MDL：
MFCD00075680

核磁/質(zhì)譜：

品牌	貨號(hào)	產(chǎn)品規(guī)格	價(jià)格(RMB)	庫(kù)存（上海）	北京	武漢	南京	計(jì)量單位	加入購(gòu)物車(chē)...
源葉	B21682-20mg	分析標(biāo)準(zhǔn)品,HPLC≥98%	￥350.00元	>10	3	-	2	EA	加入購(gòu)物車(chē)
源葉	B21682-100mg	分析標(biāo)準(zhǔn)品,HPLC≥98%	￥1300.00元	>10	-	-	-	EA	加入購(gòu)物車(chē)
源葉	B21682-500mg	分析標(biāo)準(zhǔn)品,HPLC≥98%	￥2600.00元	2	-	-	-	EA	加入購(gòu)物車(chē)
源葉	B21682-1g	分析標(biāo)準(zhǔn)品,HPLC≥98%	￥4050.00元	1	-	-	-	EA	加入購(gòu)物車(chē)

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產(chǎn)品介紹

參考文獻(xiàn)(42篇)

質(zhì)檢證書(shū)(COA)

摩爾濃度計(jì)算器

相關(guān)產(chǎn)品

介紹：
Shikonin 是中草藥紫草的主要成分。Shikonin 是一種有效的 TMEM16A 氯化物通道 (chloride channel) 抑制劑，IC50 為 6.5 μM。Shikonin 是一種特異的丙酮酸激酶 M2 (PKM2) 抑制劑，還可以抑制 TNF-α 和 NF-κB途徑。Shikonin 通過(guò)抑制糖酵解降低外泌體 (exosome) 的分泌。Shikonin 抑制 AIM2炎性體活化。

熔點(diǎn)： 147°C

沸點(diǎn)： 567.4°C at 760 mmHg

外觀：紫色片狀結(jié)晶或結(jié)晶性粉末

溶解性： DMSO : 25 mg/mL (86.72 mM; ultrasonic and warming and heat to 60°C)

儲(chǔ)存條件： 2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

42. [IF=0] Danmeng Bai et al."Rapid formed temperature-sensitive hydrogel for the multi-effective wound healing of deep second-degree burn with shikonin based scar prevention."Biomaterials Advances".2024 Jun;160:213851

41. [IF=6] Yangli Wan et al."Anti Staphylococcus aureus activity of shikonin @ chitosan nanoemulsion and its effect on the storage quality of pork."FOOD CONTROL.2024 Apr;158:110203

40. [IF=4.4] Hongwei Han et al."Novel shikonin derivative suppresses tumor growth and metastasis intervention of Wnt/β-catenin pathway."PROCESS BIOCHEMISTRY.2023 Sep;132:297

39. [IF=4.5] Xudong Zhou et al."Degradation pathways and mechanisms insight of indigo and shikonin with experiments and quantum chemical calculations."DYES AND PIGMENTS.2023 Oct;218:111455

38. [IF=8.025] Sicheng Liang et al."A comparative investigation of catalytic mechanism and domain between catechol-O-methyltransferase isoforms by isomeric shikonin and alkannin."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2023 May;:124758

37. [IF=4.927] Cheng-Zhu Wu et al."Isobavachalcone Induces Multiple Cell Death in Human Triple-Negative Breast Cancer MDA-MB-231 Cells."MOLECULES.2022 Jan;27(20):6787

36. [IF=5.714] Hongyan Lin et al."Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer."INTERNATIONAL IMMUNOPHARMACOLOGY.2022 Oct;111:109097

35. [IF=2.267] Na Zhao et al."Rapid Qualitative and Quantitative Characterization of Arnebiae Radix by Near-Infrared Spectroscopy (NIRS) with Partial Least Squares—Discriminant Analysis (PLS-DA)."ANALYTICAL LETTERS

34. [IF=5.811]

33. [IF=4.35] Yangli Wan et al."Control of Foodborne Staphylococcus aureus by Shikonin, a Natural Extract."Foods. 2021 Dec;10(12):2954

32. [IF=3.981] Luhua Meng et al."Hyaluronic acid-coated shikonin liposomes for the treatment of triple-negative breast cancer via targeting tumor cells and amplification of oxidative stress."J Drug Deliv Sci Tec. 2022 Apr;70:103193

31. [IF=7.848] Mingyue Zhou et al."Oriented Layered Graphene Oxide Pad Favoring High Loading Capacity and Stability for High-Throughput Chemical Screening."Advanced Materials Technologies. 2022 Mar 11

30. [IF=5.81] Jieli Pan et al.Up-Regulation of p53/miR-628-3p Pathway, a Novel Mechanism of Shikonin on Inhibiting Proliferation and Inducing Apoptosis of A549 and PC-9 Non-Small Cell Lung Cancer Cell Lines.Front Pharmacol. 2021 Nov 16;12:766165

29. [IF=1.312] Xu Wang et al."Microwave-assisted ionic liquid microextraction combined with high performance liquid chromatography for the determination of naphthoquinones from Arnebia euchroma (Royle) Johnst."Journal Of Liquid Chromatography & Related Technologies. 20

28. [IF=1.785] Fang Zhang et al."Non?cytotoxic doses of shikonin inhibit lipopolysaccharide?induced TNF?α expression via activation of the AMP?activated protein kinase signaling pathway."Exp Ther Med. 2020 Nov;20(5):1-1

27. [IF=2.952] Liying Sha et al."Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer."Mol Med Rep. 2021 Aug;24(2):1-10

26. [IF=3.69] Chunfang Liu et al."Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways."J Ethnopharmacol. 2020 Oct;260:113039

25. [IF=4.545] Kai Chen et al."Shikonin mitigates ovariectomy-induced bone loss and RANKL-induced osteoclastogenesis via TRAF6-mediated signaling pathways."Biomed Pharmacother. 2020 Jun;126:110067

24. [IF=5.279] Wenqin Li et al."Discovery of Natural Products as Multitarget Inhibitors of Insect Chitinolytic Enzymes through High-Throughput Screening."J Agr Food Chem. 2021;69(37):10830–10837

23. [IF=5.455] He Lianhua et al."Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes."Chin Med-Uk. 2021 Dec;16(1):1-15

22. [IF=5.81] Liu Yun-zi et al."Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation."Front Pharmacol. 2021 Oct;0:2888

21. [IF=1.312] Qi Zhang et al."Rapid and sensitive determination of shikonin and its derivatives in the roots of Arnebia euchroma (Royle) Johnst using matrix solid-phase dispersion extraction and ultrahigh-performance liquid chromatography with photodiode array detecto

20. [IF=2.896] Lu Wang et al."Rapid assay for testing superoxide anion radical scavenging activities to natural pigments by ultra-high performance liquid chromatography-diode-array detection method."Anal Methods-Uk. 2015 Feb;7(4):1535-1542

19. [IF=2.985] Chao Yang et al."Shikonin exerts anti-inflammatory effects in LPS-induced mastitis by inhibiting NF-κB signaling pathway."Biochem Bioph Res Co. 2018 Oct;505:1

18. [IF=3.06] Xianchun Wen et al."Anticancer Efficacy of Targeted Shikonin Liposomes Modified with RGD in Breast Cancer Cells."Molecules. 2018 Feb;23(2):268

17. [IF=3.547] Heyong Wang et al."Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway."Toxicology. 2013 Jun;308:104

16. Chunfang Liu, Lianhua He, Jingxia Wang, Qianqian Wang, Congcong Sun, Yiqun Li, Kexin Jia, Jinxia Wang, Tengteng Xu, Ruirui Ming, Qingwen Wang, Na Lin, Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling

15. Han Y, Shen M, Tang LY, Tan G, Yang QC, Ye L, Ye LH, Jiang N, Gao GP, Shao Y, Shao Y, et al: Antiangiogenic effects of catalpol on rat corneal neovascularization. Mol Med Rep 17: 2187-2194, 2018

14. Wen, Xianchun, et al. "Anticancer efficacy of targeted shikonin liposomes modified with RGD in breast cancer cells." Molecules 23.2 (2018): 268.https://doi.org/10.3390/molecules23020268

13. Heyong Wang, Chunlian Wu, Shengbang Wan, Huijun Zhang, Songwen Zhou, Gentao Liu, Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway, Toxicology, Volume

12. Chao Yang, Pei Liu, Shuang Wang, Gan Zhao, Tao Zhang, Shuai Guo, KangFeng Jiang, HaiChong Wu, Ganzhen Deng, Shikonin exerts anti-inflammatory effects in LPS-induced mastitis by inhibiting NF-κB signaling pathway, Biochemical and Biophysical Research Commun

11. 崔偉亮. 丹參酒炙前后HPLC指紋圖譜色譜峰歸屬比較[J]. 遼寧中醫(yī)雜志, v.46;No.507(08):1707-1709.

10. 牛敏劉紅燕劉謙等. 4個(gè)栽培年限丹參顏色與9種活性成分含量的相關(guān)性[J]. 中成藥 2017(1):131-135.

9. 孫健文溫憲春蔡德富等. RP-HPLC法同時(shí)測(cè)定新疆紫草中紫草素、乙酰紫草素、β β-二甲基丙烯酰紫草素的含量[J]. 中國(guó)藥房 2018 v.29;No.622(04):455-457.

8. 徐翊雯, 袁瑞娟, 董潔,等. 紫草素鋅配合物的合成及其對(duì)人宮頸癌HeLa細(xì)胞的抑制作用[J]. 中醫(yī)學(xué)報(bào), 2016(3):316-318.

7. 路京, 陳子龍, 閔朕,等. 紫草素逆轉(zhuǎn)由肝細(xì)胞生長(zhǎng)因子誘導(dǎo)的肺癌吉非替尼耐藥[J]. 中國(guó)病理生理雜志, 2019, 35(01):68-73.

6. 王媛, 劉莉, 陸遠(yuǎn),等. 紫草素逆轉(zhuǎn)?？颂婺釋?duì)肺癌EGFR-TKI耐藥及其機(jī)制的研究[J]. 現(xiàn)代生物醫(yī)學(xué)進(jìn)展, 2016, 16(016):3044-3047.

5. 魏玉, 康冰亞, 張明昊,等. 紫草素納米乳的制備及其穩(wěn)定性考察[J]. 時(shí)珍國(guó)醫(yī)國(guó)藥, 2018, 29(12):2932-2935.

4. 趙莎, 潘敏, 陳菲菲,等. 紫草素對(duì)銀屑病樣動(dòng)物模型Th17細(xì)胞相關(guān)因子的影響[J]. 臨床皮膚科雜志, 2016, 045(005):323-327.

3. 周海, 伍春蓮, 徐佳,等. 紫草素對(duì)人結(jié)腸癌細(xì)胞Lovo增殖與凋亡的影響[J]. 西華師范大學(xué)學(xué)報(bào)(自然科學(xué)版), 2014, 35(002):135-139.

2. 李發(fā)凱, 張芳, 陸遠(yuǎn),等. 紫草素促進(jìn)肺癌A549細(xì)胞凋亡[J]. 現(xiàn)代生物醫(yī)學(xué)進(jìn)展, 2018, 018(009):1611-1615,1673.

1. 顧依周琴劉馨刁和芳陳志鵬陳瑞朱辰奇.丹參聚多巴胺納米遞藥系統(tǒng)的構(gòu)建及對(duì)H_2O_2誘導(dǎo)心肌細(xì)胞氧化損傷的保護(hù)作用研究[J].中草藥 2020 51(14):3655-3662.