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S80039

BAY 80-6946 (Copanlisib)

源葉(MedMol) 98%
  • 英文名:
  • BAY 80-6946 (Copanlisib)
  • 別名:
  • 2-氨基-N-[2,3-二氫-7-甲氧基-8-[3-(4-嗎啉基)丙氧基]咪唑并[1,2-C]喹唑啉-5-基]-5-嘧啶甲酰胺;BAY 80-6946; 2-Amino-N.N-diaethyl-toluolsulfonamid-(4); 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quina
  • CAS號(hào):
  • 1032568-63-0
  • 分子式:
  • C23H28N8O4
  • 分子量:
  • 480.52
  • 核磁/質(zhì)譜:
品牌貨號(hào)產(chǎn)品規(guī)格價(jià)格(RMB) 庫(kù)存(上海) 北京 武漢 南京 數(shù)量計(jì)量單位 加入購(gòu)物車...
源葉(MedMol) S80039-1mg 98% ¥391.00元 4 - - - EA 加入購(gòu)物車
源葉(MedMol) S80039-2mg 98% ¥561.00元 5 - - - EA 加入購(gòu)物車
源葉(MedMol) S80039-5mg 98% ¥930.00元 5 - - - EA 加入購(gòu)物車
源葉(MedMol) S80039-10mg 98% ¥1490.00元 5 - - - EA 加入購(gòu)物車
源葉(MedMol) S80039-25mg 98% ¥2750.00元 6 - - - EA 加入購(gòu)物車
源葉(MedMol) S80039-50mg 98% ¥4100.00元 5 - - - EA 加入購(gòu)物車
源葉(MedMol) S80039-100mg 98% ¥5800.00元 5 - - - EA 加入購(gòu)物車
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產(chǎn)品介紹

參考文獻(xiàn)

質(zhì)檢證書(shū)(COA)

摩爾濃度計(jì)算器

相關(guān)產(chǎn)品

  • 提示:詳情請(qǐng)下載說(shuō)明書(shū)。
  • 產(chǎn)品描述: Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity
  • 靶點(diǎn): PI3Kα:0.5 nM (IC50);PI3Kβ:3.7 nM (IC50);PI3Kδ:0.7 nM (IC50);PI3Kγ:6.4 nM (IC50);mTOR:45 nM (IC50);Apoptosis;PI3K
  • 體內(nèi)研究:
    Copanlisib (BAY 80-6946; 0.5-6 mg/kg; intravenous injection; every second day, every third day; for 60 days; athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model
  • 參考文獻(xiàn):
    1. Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30.
  • 溶解性: 1M  HCl  :  100  mg/mL  (208.11  mM;  Need  ultrasonic)
  • 保存條件: -20℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 2.081 ml 10.405 ml 20.811 ml
    5 mM 0.416 ml 2.081 ml 4.162 ml
    10 mM 0.208 ml 1.041 ml 2.081 ml
    50 mM 0.042 ml 0.208 ml 0.416 ml
  • 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
  • 提示:詳情請(qǐng)下載說(shuō)明書(shū)。
  • 產(chǎn)品描述: Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity
  • 靶點(diǎn): PI3Kα:0.5 nM (IC50);PI3Kβ:3.7 nM (IC50);PI3Kδ:0.7 nM (IC50);PI3Kγ:6.4 nM (IC50);mTOR:45 nM (IC50);Apoptosis;PI3K
  • 體內(nèi)研究:
    Copanlisib (BAY 80-6946; 0.5-6 mg/kg; intravenous injection; every second day, every third day; for 60 days; athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model
  • 參考文獻(xiàn):
    1. Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30.
  • 溶解性: 1M  HCl  :  100  mg/mL  (208.11  mM;  Need  ultrasonic)
  • 保存條件: -20℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 2.081 ml 10.405 ml 20.811 ml
    5 mM 0.416 ml 2.081 ml 4.162 ml
    10 mM 0.208 ml 1.041 ml 2.081 ml
    50 mM 0.042 ml 0.208 ml 0.416 ml
  • 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
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質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)


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