S80039 |
BAY 80-6946 (Copanlisib) |
源葉(MedMol) | 98% |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.081 ml | 10.405 ml | 20.811 ml |
5 mM | 0.416 ml | 2.081 ml | 4.162 ml |
10 mM | 0.208 ml | 1.041 ml | 2.081 ml |
50 mM | 0.042 ml | 0.208 ml | 0.416 ml |
- 提示:詳情請(qǐng)下載說(shuō)明書(shū)。
- 產(chǎn)品描述: Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity
- 靶點(diǎn): PI3Kα:0.5 nM (IC50);PI3Kβ:3.7 nM (IC50);PI3Kδ:0.7 nM (IC50);PI3Kγ:6.4 nM (IC50);mTOR:45 nM (IC50);Apoptosis;PI3K
- 體內(nèi)研究:
Copanlisib (BAY 80-6946; 0.5-6 mg/kg; intravenous injection; every second day, every third day; for 60 days; athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model
- 參考文獻(xiàn):
1. Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30.
- 溶解性: 1M HCl : 100 mg/mL (208.11 mM; Need ultrasonic)
- 保存條件: -20℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 2.081 ml 10.405 ml 20.811 ml 5 mM 0.416 ml 2.081 ml 4.162 ml 10 mM 0.208 ml 1.041 ml 2.081 ml 50 mM 0.042 ml 0.208 ml 0.416 ml
- 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
輸入產(chǎn)品批號(hào):
本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:
質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)