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• 產(chǎn)品描述： SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.

• 靶點(diǎn)： FGFR;PDGFR;VEGFR;VEGFR;FGFR;PDGFR

• 體內(nèi)研究：
  In mice, SU5416 (25 mg/kg, i.p.) inhibits subcutaneous growth of a panel of tumor cell lines by inhibiting the angiogenic process associated with tumor growth.

• 細(xì)胞實(shí)驗(yàn)： Tumor cell lines used in the in vitro growth are cultured in media at 37°C in 5–10% CO2. SU5416 is serially diluted in media containing DMSO (<0.5%) and added to cultures of tumor cells 1 day after the initiation of culture. Cell growth is measured after 96 h using the sulforhodamine B method. IC50s are calculated by curve fitting using four-parameter analysis.(Only for Reference)

• 參考文獻(xiàn)：
  1.Li Y, et al. Calcif Tissue Int. 2013, 93(6), 556-5 64. 2.Sun L, et al. J Med Chem. 1999, 42(25), 5120-5130. 3.Lo AK, et al. J Pathol. 2015. doi: 10.12002/path.4575. 4.Fong TA, et al. Cancer Res. 1999, 59(1), 99-106. 5.Trzcińska-Daneluti AM, et al. RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR. Mol Cell Proteomics. 2015 Jun;14(6):1569-83.

• 溶解性： DMSO:29.6  mg/mL  (100  mM)

• 保存條件： 2-8℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.375 ml	16.874 ml	33.747 ml
  5 mM	0.675 ml	3.375 ml	6.749 ml
  10 mM	0.337 ml	1.687 ml	3.375 ml
  50 mM	0.067 ml	0.337 ml	0.675 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *