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• 產品描述： Leonurine hydrochloride is an alkaloid isolated from Leonurus artemisia, with anti-oxidative and anti-inflammatory.

• 靶點： Autophagy;TLR;?Autophagy

• 體內研究：
  Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20?mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model

• 參考文獻：
  1. Jiang T, et al. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner. Cell Physiol Biochem. 2017;43(4):1703-1717. 2. Zhang L, et al. Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway. Biomed Pharmacother. 2018 Dec 7;110:571-581. 3. Hu ZC, et al. Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. J Cell Physiol. 2018 Nov 11.

• 溶解性： DMSO  :  ≥  31  mg/mL  (89.13  mM)    H2O  :  5  mg/mL  (14.38  mM;  Need  ultrasonic)

• 保存條件： RT

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.875 ml	14.376 ml	28.752 ml
  5 mM	0.575 ml	2.875 ml	5.75 ml
  10 mM	0.288 ml	1.438 ml	2.875 ml
  50 mM	0.058 ml	0.288 ml	0.575 ml

• 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

輸入產品批號：

本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系，公式為：

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *