• 產品描述： A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain

• 靶點： GSK-3α:0.6 nM (ki), GSK-3β:0.6 nM (ki);GSK-3

• 體內研究：
  PET imaging experiments in anesthetized vervet/African green monkey exhibited that A 1070722 penetrated the blood-brain barrier (BBB) and accumulated in brain regions, with highest radioactivity binding in frontal cortex followed by parietal cortex and anterior cingulate, and with the lowest bindings found in caudate, putamen, and thalamus, similarly to the known distribution of GSK-3 in human brain

• 參考文獻：
  1. Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703.

• 溶解性： Soluble  in  DMSO

• 保存條件： 2-8°C

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.76 ml	13.8 ml	27.601 ml
  5 mM	0.552 ml	2.76 ml	5.52 ml
  10 mM	0.276 ml	1.38 ml	2.76 ml
  50 mM	0.055 ml	0.276 ml	0.552 ml

• 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

輸入產品批號：

本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系，公式為：

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *