| 產(chǎn)品描述： | ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease |
| 靶點(diǎn)： |
EC50: 0.4 μM (glucocerebrosidase);Glucokinase |
| 體外研究： |
ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr.
ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 μM, compared to 5% of DMSO) in human fibroblasts.
ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility. |
| 參考文獻(xiàn)： |
1. Steven Rogers, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. |
| 溶解性： |
Soluble in DMSO |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.444 ml |
17.222 ml |
34.445 ml |
| 5 mM |
0.689 ml |
3.444 ml |
6.889 ml |
| 10 mM |
0.344 ml |
1.722 ml |
3.444 ml |
| 50 mM |
0.069 ml |
0.344 ml |
0.689 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
危險(xiǎn)品化學(xué)品經(jīng)營(yíng)許可證（不帶存儲(chǔ)）
營(yíng)業(yè)執(zhí)照(三證合一)
北京