| 產(chǎn)品描述： | NSC 23766 trihydrochloride is an inhibitor of Rac1 activation. |
| 靶點(diǎn)： |
Ras;Apoptosis;Apoptosis;Rho;Ras |
| 體內(nèi)研究： |
NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice |
| 參考文獻(xiàn)： |
1. Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39(2):760-7. 2. Song SJ, et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3;6:34415 3. Zhao L, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6;6:23972 4. Wang Y, et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar;173(5):937-50 |
| 溶解性： |
DMSO : 33.33 mg/mL (62.77 mM; Need ultrasonic) H2O : ≥ 32 mg/mL (60.27 mM) |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.883 ml |
9.417 ml |
18.834 ml |
| 5 mM |
0.377 ml |
1.883 ml |
3.767 ml |
| 10 mM |
0.188 ml |
0.942 ml |
1.883 ml |
| 50 mM |
0.038 ml |
0.188 ml |
0.377 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。 |
上海工商
危險(xiǎn)品化學(xué)品經(jīng)營(yíng)許可證（不帶存儲(chǔ)）
營(yíng)業(yè)執(zhí)照(三證合一)
掃一掃關(guān)注上海源葉微信公眾號(hào)
北京