貨號	規(guī)格	價格	上海	北京	武漢	南京
S80169-5mg	≥99%	￥850.00 S80169-5mg ￥850.00 現(xiàn)貨	10 10	-	-	-
S80169-10mg	≥99%	￥1530.00 S80169-10mg ￥1530.00 現(xiàn)貨	10 10	-	-	-
S80169-25mg	≥99%	￥3100.00 S80169-25mg ￥3100.00 現(xiàn)貨	8 8	-	-	-
S80169-50mg	≥99%	￥4839.00 S80169-50mg ￥4839.00 現(xiàn)貨	7 7	-	-	-
S80169-100mg	≥99%	￥7739.00 S80169-100mg ￥7739.00 現(xiàn)貨	6 6	-	-	-

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產(chǎn)品介紹

GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.

產(chǎn)品描述：

GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.

靶點：

mTOR:3.8 nM (Ki);mTORC1p;mTORC2;Autophagy ;PI3K;mTOR;Autophagy

體內(nèi)研究：

When dosed orally once daily in athymic mice in a MCF7-neo/Her2 tumor xenograft model (PI3K mutation), GDC-0349 (Compound 8h) inhibits tumor growth in a dose-dependent manner, achieving stasis (99% TGI) at the maximum tolerated dose. Body weight change is less than 10% up to the highest dose. GDC-0349 is also efficacious in other xenograft models, including PC3 (PTEN null) and 786-0 (VHL mutant). Similar levels of tumor growth inhibition are achieved when GDC-0349 is administered once every three days at higher doses compared to once every day. GDC-0349 has ~10-fold reduced free plasma clearance in both mice (100 mL/min/kg) and rats (171 mL/min/kg in rat)

參考文獻(xiàn)：

1. Pei Z, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.21 ml	11.049 ml	22.097 ml
5 mM	0.442 ml	2.21 ml	4.419 ml
10 mM	0.221 ml	1.105 ml	2.21 ml
50 mM	0.044 ml	0.221 ml	0.442 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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GDC-0349