S80170 |
N6022 |
源葉(MedMol) | 98% |
品牌 | 貨號 | 產品規(guī)格 | 價格(RMB) | 庫存(上海) | 北京 | 武漢 | 南京 | 數量 | 計量單位 | 加入購物車... |
---|---|---|---|---|---|---|---|---|---|---|
源葉(MedMol) | S80170-1mg | 98% | ¥232.00元 | 5 | 0 | 0 | 0 | EA | 加入購物車 | |
源葉(MedMol) | S80170-2mg | 98% | ¥416.00元 | 9 | 0 | 0 | 0 | EA | 加入購物車 | |
源葉(MedMol) | S80170-5mg | 98% | ¥640.00元 | 8 | 0 | 0 | 0 | EA | 加入購物車 | |
源葉(MedMol) | S80170-10mg | 98% | ¥960.00元 | 9 | 0 | 0 | 0 | EA | 加入購物車 | |
源葉(MedMol) | S80170-25mg | 98% | ¥1920.00元 | 7 | 0 | 0 | 0 | EA | 加入購物車 | |
源葉(MedMol) | S80170-50mg | 98% | ¥3360.00元 | 5 | 0 | 0 | 0 | EA | 加入購物車 | |
源葉(MedMol) | S80170-100mg | 98% | ¥4480.00元 | 2 | 0 | 0 | 0 | EA | 加入購物車 |
- 提示:詳情請下載說明書。
- 產品描述: N6022(IC50 of 8 nM) is an effective, reversible, and selective S-Nitrosoglutathione reductase(GSNOR) inhibitor.
- 靶點: GSNOR
- 體外研究:
N6022 binds to rat plasma proteins in a concentration-dependent manner. At lower drug concentrations (20 μM), N6022 show more effect on ATP than on GSH. N6022 (IC50 of 8 nM and a Ki of 2.5 nM) binds in the GSNO substrate binding pocket like a competitive inhibitor. N6022 is uncompetitive with cofactors NAD+ and NADH.
- 體內研究:
N6022 treats rats in 50 mg/kg leading to a slight increase in the incidence of granulomas. In serum, N6022 remained in solution is up to 5 mg/mL.
- 細胞實驗: N6022 is dissolved in 5% DMSO. N6022 is tested using a rat hepatoma (H4IIE) cell line whereby cells are seeded into 96-well plates and cultured in medium containing 20% bovine serum. Following an equilibration period of 48 h, the cells are treated with N6022 (5% DMSO vehicle) at concentrations of 0, 1, 5, 10, 20, 50, 100, and 300 μM for 24 h at 37°C in 5% CO2. Camptothecin and rotenone are included as positive controls. The cell supernatant or the cells themselves are harvested for biochemical analysis.
- 參考文獻:
1. Green LS, et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012, 51(10), 2157-2168 2. Sun X, et al. Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases. ACS Med Chem Lett. 2011, 2(5), 402-406.
- 溶解性: soluble in DMSO
- 保存條件: -20℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 2.413 ml 12.064 ml 24.128 ml 5 mM 0.483 ml 2.413 ml 4.826 ml 10 mM 0.241 ml 1.206 ml 2.413 ml 50 mM 0.048 ml 0.241 ml 0.483 ml
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質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)
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