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SD-208 98%

SD-208

源葉(MedMol)
S80850
627536-09-8
C17H10ClFN6
352.75
MFCD11519969
品牌 貨號(hào) 產(chǎn)品規(guī)格 價(jià)格(RMB) 庫(kù)存（上海） 北京 武漢 南京 購(gòu)買數(shù)量
源葉(MedMol) S80850-5mg 98% ￥90.00元 5 - - -
源葉(MedMol) S80850-10mg 98% ￥140.00元 7 - - -
源葉(MedMol) S80850-25mg 98% ￥290.00元 6 - - -
源葉(MedMol) S80850-50mg 98% ￥480.00元 5 - - -
源葉(MedMol) S80850-100mg 98% ￥760.00元 5 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, and > 100-fold selectivity over TGF-βRII.
產(chǎn)品描述： SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, and > 100-fold selectivity over TGF-βRII.
靶點(diǎn)： IC50: 48 nM (TGF-βRI);TGF-beta/Smad
體內(nèi)研究：
SD-208 (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice. In syngeneic 129S1 mice, SD-208 (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases. In the murine aortic allograft model, SD-208 effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA)
參考文獻(xiàn)：
1. Uhl M, et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004 Nov 1;64(21):7954-61. 2. Ge R, et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4315-30. 3. Sun Y, et al. Inhibition of intimal hyperplasia in murine aortic allografts by the oral administration of the transforming growth factor-beta receptor I kinase inhibitor SD-208. J Heart Lung Transplant. 2014 Jun;33(6):654-61.
溶解性： DMSO  :  9.09  mg/mL  (25.77  mM;  Need  ultrasonic)
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 2.835 ml 14.174 ml 28.349 ml
5 mM 0.567 ml 2.835 ml 5.67 ml
10 mM 0.283 ml 1.417 ml 2.835 ml
50 mM 0.057 ml 0.283 ml 0.567 ml
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參考文獻(xiàn)

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