貨號	規(guī)格	價格	上海	北京	武漢	南京
S81219-2mg	99%	￥150.00 S81219-2mg ￥150.00 現(xiàn)貨	5 5	-	-	-
S81219-5mg	99%	￥226.00 S81219-5mg ￥226.00 現(xiàn)貨	6 6	-	-	-
S81219-10mg	99%	￥420.00 S81219-10mg ￥420.00 現(xiàn)貨	6 6	-	-	-
S81219-25mg	99%	￥610.00 S81219-25mg ￥610.00 現(xiàn)貨	5 5	-	-	-
S81219-50mg	99%	￥850.00 S81219-50mg ￥850.00 2-3天	0 貨期：2-3天	-	-	-
S81219-100mg	99%	￥1330.00 S81219-100mg ￥1330.00 2-3天	0 貨期：2-3天	-	-	-
S81219-200mg	99%	￥2400.00 S81219-200mg ￥2400.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5).

產(chǎn)品描述：

HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5).

靶點(diǎn)：

Protein arginine methyltransferase 5;Apoptosis;?HistoneMethyltransferase

體外研究：

HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively[1].HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12?h post-treatment and persisting after 48?h. Cell Viability Assay Cell Line: MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients) Concentration: 1, 5, 10, 25, 50, 100 μM Incubation Time: 24, 48, 72 hours Result: Dose-dependent reduction in cell viability with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.

參考文獻(xiàn)：

1. Tarighat SS, et al. The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. Leukemia. 2016 Apr;30(4):789-99.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.625 ml	13.126 ml	26.253 ml
5 mM	0.525 ml	2.625 ml	5.251 ml
10 mM	0.263 ml	1.313 ml	2.625 ml
50 mM	0.053 ml	0.263 ml	0.525 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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HLCL-61 (hydrochloride)