| 產(chǎn)品描述： | MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM) |
| 靶點(diǎn)： |
IC50: 74/47 μM (Tip60/MOF);Apoptosis;?Others;?EpigeneticReaderDomain;?HistoneAcetyltransferase |
| 體外研究： |
MG 149 (Tip60 HAT inhibitor), at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentially competitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extracts of different regions significantly (p < 0.05). |
| 參考文獻(xiàn)： |
1. Ghizzoni M, et al. 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44. |
| 溶解性： |
soluble in DMSO |
| 保存條件： |
-20℃ |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.937 ml |
14.686 ml |
29.372 ml |
| 5 mM |
0.587 ml |
2.937 ml |
5.874 ml |
| 10 mM |
0.294 ml |
1.469 ml |
2.937 ml |
| 50 mM |
0.059 ml |
0.294 ml |
0.587 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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