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ABT-199 Venetoclax

    
99%

ABT-199 Venetoclax

源葉(MedMol)
S81268 一鍵復(fù)制產(chǎn)品信息
1257044-40-8
C45H50ClN7O7S
868.44
維萘妥拉;[2H7]-Venetoclax;Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數(shù)量
S81268-2mg 99% ¥204.00 9 - - -
S81268-5mg 99% ¥382.50 >10 - - -
S81268-10mg 99% ¥510.00 8 - - -
S81268-50mg 99% ¥890.00 >10 - - -
S81268-100mg 99% ¥1160.00 7 - - -
S81268-1g 99% ¥4500.00 6 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy

產(chǎn)品描述:

Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy

靶點: Bcl-2:0.01 nM (Ki);Bcl-xL:48 nM (Ki);Bcl-W:245 nM (Ki);BCL;?Autophagy
體內(nèi)研究: After a single oral dose of 12.5 mg per kg body weight in xenografts derived from RS4;11 cells (ALL), Venetoclax (ABT-199) causes a maximal tumor growth inhibition (TGImax) of 47% (P<0.001) and tumor growth delay (TGD) of 26% (P<0.05). Treatment of established xenografted (a mouse xenograft model of the T-ALL cell line LOUCY) tumors with Venetoclax (ABT-199) 100 mg/kg for 4 days results in a significant reduction of leukemic burden.
參考文獻(xiàn): 1. Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8. 2. Peirs S, et al. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. Blood. 2014 Dec 11;124(25):3738-47. 3. Bi C, et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102(4):755-764.
溶解性: DMSO  :  77.5  mg/mL  (89.24  mM;  Need  ultrasonic)    Ethanol  :  <  1  mg/mL  (insoluble)
保存條件: -20℃
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 1.151 ml 5.757 ml 11.515 ml
5 mM 0.23 ml 1.151 ml 2.303 ml
10 mM 0.115 ml 0.576 ml 1.151 ml
50 mM 0.023 ml 0.115 ml 0.23 ml
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參考文獻(xiàn)

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摩爾濃度計算器

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