| 產(chǎn)品描述： | STING inhibitor C-176是一種有效的STING抑制劑。STING是細(xì)胞內(nèi)DNA感應(yīng)通路的主要信號(hào)分子 |
| 靶點(diǎn)： |
STING |
| 體外研究： |
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. It directly targets mouse STING (mmSTING) but not human STING (hsSTING) |
| 體內(nèi)研究： |
C-176 attenuates STING-associated autoinflammatory disease in mice |
| 細(xì)胞實(shí)驗(yàn)： |
Cell lines: H526 cells Concentrations: 1?μM Incubation Time: 48 h Method: Cells were treated 1 μM C176 and 1 μM AZD1775 for 48 h |
| 動(dòng)物實(shí)驗(yàn)： |
Cell lines: H526 cells Concentrations: 1?μM Incubation Time: 48 h Method: Cells were treated 1 μM C176 and 1 μM AZD1775 for 48 h |
| 參考文獻(xiàn)： |
1. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors, Nature. 2018, 559(7713):269-273. 2. Taniguchi H, et al. WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC. Cell Rep. 2022 May 17;39(7):110814. |
| 溶解性： |
Soluble in DMSO、Ethanol |
| 保存條件： |
-20°C |
| 配置溶液濃度參考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.793 ml |
13.963 ml |
27.926 ml |
| 5 mM |
0.559 ml |
2.793 ml |
5.585 ml |
| 10 mM |
0.279 ml |
1.396 ml |
2.793 ml |
| 50 mM |
0.056 ml |
0.279 ml |
0.559 ml |
|
| 注意： |
部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。 |
上海工商
危險(xiǎn)品化學(xué)品經(jīng)營(yíng)許可證（不帶存儲(chǔ)）
營(yíng)業(yè)執(zhí)照(三證合一)
北京