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JNJ0966

    
98%

JNJ0966

源葉(MedMol)
S88647 一鍵復(fù)制產(chǎn)品信息
315705-75-0
C16H16N4O2S2
360.45
貨號(hào) 規(guī)格 價(jià)格 上海 北京 武漢 南京 購(gòu)買數(shù)量
S88647-1mg 98% ¥140.00 3 - - -
S88647-5mg 98% ¥330.00 4 - - -
S88647-10mg 98% ¥440.00 5 - - -
S88647-25mg 98% ¥590.00 4 - - -
S88647-50mg 98% ¥790.00 貨期:2-3天 - - -
S88647-100mg 98% ¥1350.00 貨期:2-3天 - - -
產(chǎn)品介紹 參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM

產(chǎn)品描述: JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM
靶點(diǎn): IC50: 440 nM (MMP-9 zymogen);MMP
體外研究: JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species
體內(nèi)研究: The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM), respectively, whereas the 30-mg/kg dose achieves 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in brain. JNJ0966 is preferentially partitioned in brain, with brain/plasma ratios of 6.2 for the 10-mg/kg dose and 4.7 for the 30-mg/kg dose
參考文獻(xiàn): 1. Scannevin RH, et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) thatallosterically inhibits zymogen activation. J Biol Chem. 2017 Oct 27;292(43):17963-17974.
溶解性: Soluble  in  DMSO
保存條件: -20°C
配置溶液濃度參考:
1mg 5mg 10mg
1 mM 2.774 ml 13.872 ml 27.743 ml
5 mM 0.555 ml 2.774 ml 5.549 ml
10 mM 0.277 ml 1.387 ml 2.774 ml
50 mM 0.055 ml 0.277 ml 0.555 ml
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參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào):JS298415 貨號(hào):S20001-25g
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摩爾濃度計(jì)算器

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