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S88647

JNJ0966

源葉(MedMol) 98%
  • 英文名:
  • JNJ0966
  • 別名:
  • CAS號:
  • 315705-75-0
  • 分子式:
  • C16H16N4O2S2
  • 分子量:
  • 360.45
  • 核磁/質譜:
品牌貨號產(chǎn)品規(guī)格價格(RMB) 庫存(上海) 北京 武漢 南京 數(shù)量計量單位 加入購物車...
源葉(MedMol) S88647-1mg 98% ¥140.00元 3 - - - EA 加入購物車
源葉(MedMol) S88647-5mg 98% ¥330.00元 4 - - - EA 加入購物車
源葉(MedMol) S88647-10mg 98% ¥440.00元 5 - - - EA 加入購物車
源葉(MedMol) S88647-25mg 98% ¥590.00元 6 - - - EA 加入購物車
源葉(MedMol) S88647-50mg 98% ¥790.00元 預計交期:2-3天 - - - EA 加入購物車
源葉(MedMol) S88647-100mg 98% ¥1350.00元 預計交期:2-3天 - - - EA 加入購物車
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摩爾濃度計算器

相關產(chǎn)品

  • 產(chǎn)品描述: JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM
  • 靶點: IC50: 440 nM (MMP-9 zymogen);MMP
  • 體外研究:
    JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species
  • 體內研究:
    The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM), respectively, whereas the 30-mg/kg dose achieves 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in brain. JNJ0966 is preferentially partitioned in brain, with brain/plasma ratios of 6.2 for the 10-mg/kg dose and 4.7 for the 30-mg/kg dose
  • 參考文獻:
    1. Scannevin RH, et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) thatallosterically inhibits zymogen activation. J Biol Chem. 2017 Oct 27;292(43):17963-17974.
  • 溶解性: Soluble  in  DMSO
  • 保存條件: -20°C
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 2.774 ml 13.872 ml 27.743 ml
    5 mM 0.555 ml 2.774 ml 5.549 ml
    10 mM 0.277 ml 1.387 ml 2.774 ml
    50 mM 0.055 ml 0.277 ml 0.555 ml
  • 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。
  • 產(chǎn)品描述: JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM
  • 靶點: IC50: 440 nM (MMP-9 zymogen);MMP
  • 體外研究:
    JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species
  • 體內研究:
    The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM), respectively, whereas the 30-mg/kg dose achieves 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in brain. JNJ0966 is preferentially partitioned in brain, with brain/plasma ratios of 6.2 for the 10-mg/kg dose and 4.7 for the 30-mg/kg dose
  • 參考文獻:
    1. Scannevin RH, et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) thatallosterically inhibits zymogen activation. J Biol Chem. 2017 Oct 27;292(43):17963-17974.
  • 溶解性: Soluble  in  DMSO
  • 保存條件: -20°C
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 2.774 ml 13.872 ml 27.743 ml
    5 mM 0.555 ml 2.774 ml 5.549 ml
    10 mM 0.277 ml 1.387 ml 2.774 ml
    50 mM 0.055 ml 0.277 ml 0.555 ml
  • 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。
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本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系,公式為:


質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)


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