產(chǎn)品介紹

多巴胺能選擇性神經(jīng)毒素;Dopaminergic selective neurotoxin;產(chǎn)品介紹：?1-甲基-4-苯基吡啶（MPP+）可通過(guò)抑制紋狀體突觸體中的線粒體氧化還原功能而誘發(fā)神經(jīng)毒性。它是一種潛在的神經(jīng)毒素并可在動(dòng)物模型中誘導(dǎo)帕金森癥。它可通過(guò)在小腦顆粒神經(jīng)元和神經(jīng)母細(xì)胞瘤細(xì)胞中產(chǎn)生活性氧來(lái)介導(dǎo)細(xì)胞凋亡。MPP+可調(diào)控多巴胺的分布。它可通過(guò)激活神經(jīng)元一氧化氮合酶（nNOS）而引起神經(jīng)毒性，產(chǎn)生過(guò)量的一氧化氮。 產(chǎn)品應(yīng)用： MPP+碘化物已用于： 在斑馬魚(yú)胚胎中誘導(dǎo)氧化應(yīng)激 抑制星形膠質(zhì)細(xì)胞線粒體中谷氨酸的攝入 在小膠質(zhì)細(xì)胞（BV2）中使用MTT（3（4,5-二甲基噻唑）-2-基-2,5-二苯基四唑溴化物）檢測(cè)細(xì)胞活力;Product Describtion:1-Methyl-4-phenylpyridinium (MPP+) induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide. Product Application： MPP+ iodide has been used: to induce oxidative stress in zebrafish embryos for the inhibition of glutamate uptake in mitochondria of astrocytes in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells